Walking the tightrope: proteostasis and neurodegenerative disease

Walking the Information Overload Tightrope

This chapter asks: What is information overload? At what levels of existence does it occur? Are there any features common to information overload at all these levels? What are information overload’s types? What are information overload’s current and future trends? What problems do they pose? How can they be addressed in both effective and morally justified ways? It argues that there is anarchy ...

Lecture 8: Edge Tracking – Walking the Tightrope

In the subcritical transition scenario, there is typically a regime where the linearly stable basic state coexists with the turbulent state. The simplest model of this is a 1D system ẏ = y(12 − y)(y − 1) where the basic state is y = 0, the ‘turbulent’ state is y = 1 and there is an intermediate state y = 12 which separates initial conditions which become turbulent (if y(0) > 12 then y(t) → 1 as...

A chaperome subnetwork safeguards proteostasis in aging and neurodegenerative disease.

Chaperones are central to the proteostasis network (PN) and safeguard the proteome from misfolding, aggregation, and proteotoxicity. We categorized the human chaperome of 332 genes into network communities using function, localization, interactome, and expression data sets. During human brain aging, expression of 32% of the chaperome, corresponding to ATP-dependent chaperone machines, is repres...

Balancing Selection: Walking a Tightrope

Combining modern transgenic techniques with fitness measurements and enzyme activity assays, a new study demonstrates a habitat-dependent tradeoff between two alleles of a key detoxification enzyme in fruit flies. The elegant findings provide concrete, elusive evidence supporting a foundational and controversial theory about the maintenance of genetic variation.

Walking the tightrope on Medicare reform.